Intramedullary Nailing vs Sliding Hip Screw in Trochanteric Fracture Management: The INSITE Randomized Clinical Trial.

Importance: Fractures of the hip have devastating effects on function and quality of life. Intramedullary nails (IMN) are the dominant implant choice for the treatment of trochanteric fractures of the hip. Higher costs of IMNs and inconclusive benefit in comparison with sliding hip screws (SHSs) convey the need for definitive evidence. Objective: To compare 1-year outcomes of patients with trochanteric fractures treated with the IMN vs an SHS. Design, Setting, and Participants: This randomized clinical trial was conducted at 25 international sites across 12 countries. Participants included ambulatory patients aged 18 years and older with low-energy trochanteric (AO Foundation and Orthopaedic Trauma Association [AO/OTA] type 31-A1 or 31-A2) fractures. Patient recruitment occurred between January 2012 and January 2016, and patients were followed up for 52 weeks (primary end point). Follow-up was completed in January 2017. The analysis was performed in July 2018 and confirmed in January 2022. Interventions: Surgical fixation with a Gamma3 IMN or an SHS. Main Outcomes and Measures: The primary outcome was health-related quality of life (HRQOL), measured by the EuroQol-5 Dimension (EQ5D) at 1-year postsurgery. Secondary outcomes included revision surgical procedure, fracture healing, adverse events, patient mobility (measured by the Parker mobility score), and hip function (measured by the Harris hip score). Results: In this randomized clinical trial, 850 patients were randomized (mean [range] age, 78.5 [18-102] years; 549 [64.6% female) with trochanteric fractures to undergo fixation with either the IMN (n = 423) or an SHS (n = 427). A total of 621 patients completed follow-up at 1 year postsurgery (304 treated with the IMN [71.9%], 317 treated with an SHS [74.2%]). There were no significant differences between groups in EQ5D scores (mean difference, 0.02 points; 95% CI, -0.03 to 0.07 points; P = .42). Furthermore, after adjusting for relevant covariables, there were no between-group differences in EQ5D scores (regression coefficient, 0.00; 95% CI, -0.04 to 0.05; P = .81). There were no between-group differences for any secondary outcomes. There were also no significant interactions for fracture stability (ß [SE] , 0.01 [0.05]; P = .82) or previous fracture (ß [SE], 0.01 [0.10]; P = .88) and treatment group. Conclusions and Relevance: This randomized clinical trial found that IMNs for the treatment of trochanteric fractures had similar 1-year outcomes compared with SHSs. These results suggest that the SHS is an acceptable lower-cost alternative for trochanteric fractures of the hip. Trial Registration: ClinicalTrials.gov Identifier: NCT01380444.

Risk assessment and green chemistry applied to waste generated in university laboratories.

Chemical reagents have become fundamental products in daily life use, they contribute in several ways to establish a high level of social development. In the case of higher education, the use of reagents allows learning thought laboratory practices. These practices must be carried out under preventative measures, in order to avoid negative impacts on the environment and human health; this generates the need to identify and classify the chemical substances used and the waste generated. This research was developed at the Faculty of Environmental Engineering at Universidad Santo Tomás in the Villavicencio campus, the objective was to apply the concepts of Green Chemistry in the laboratory guidelines, in addition to guaranteeing the proper management of the chemical waste generated. Initially, the hazard of twenty-one (21) laboratory guides based on the Globally Harmonized System (GHS) ninth revised edition (2021) was determined. Subsequently, an update was performed by applying Green Chemistry to ten (10) of the laboratory guides that represented the greatest hazards, and finally, a manual was established for the management of chemical waste resulting from laboratory practices. The results determined that in the subject of Inorganic Chemistry the guidelines Physical and Chemical Properties of the Matter presents the highest hazard index, due to lead nitrate, which was evaluated as the most hazard reagent, because of its carcinogenicity (1B) and reproductive toxicity (1A). The proposed update to the guidelines was possible by replacing the chemical substances used in order to reduce by 24% the risk associated with them and the by 50% the use of reagents in relation to the same laboratory guidelines defined in the first stage.

Environmental concerns and bioaccumulation of psychiatric drugs in water bodies - Conventional versus biocatalytic systems of mitigation.

The COVID-19 pandemic has brought increments in market sales and prescription of medicines commonly used to treat mental health disorders, such as depression, anxiety, stress, and related problems. The increasing use of these drugs, named psychiatric drugs, has led to their persistence in aquatic systems (bioaccumulation), since they are recalcitrant to conventional physical and chemical treatments typically used in wastewater treatment plants. An emerging environmental concern caused by the bioaccumulation of psychiatric drugs has been attributed to the potential ecological and toxicological risk that these medicines might have over human health, animals, and plants. Thus, by the application of biocatalysis-assisted techniques, it is possible to efficiently remove psychiatric drugs from water. Biocatalysis, is a widely employed and highly efficient process implemented in the biotransformation of a wide range of contaminants, since it has important differences in terms of catalytic behavior, compared to common treatment techniques, including photodegradation, Fenton, and thermal treatments, among others. Moreover, it is noticed the importance to monitor transformation products of degradation and biodegradation, since according to the applied removal technique, different toxic transformation products have been reported to appear after the application of physical and chemical procedures. In addition, this work deals with the discussion of differences existing between high- and low-income countries, according to their environmental regulations regarding waste management policies, especially waste of the drug industry.

Nanomaterial Constructs for Catalytic Applications in Biomedicine: Nanobiocatalysts and Nanozymes.

Nanomaterials possess superior advantages due to their special geometries, higher surface area, and unique mechanical, optical, and physicochemical properties. Their characteristics make them great contributors to the development of many technological and industrial sectors. Therefore, novel nanomaterials have an increasing interest in many research areas including biomedicine such as chronic inflammations, disease detection, drug delivery, and infections treatment. Their relevant role is, in many cases, associated with an effective catalytic application, either as a pure catalyst (acting as a nanozyme) or as a support for catalytically active materials (forming nanobiocatalysts). In this review, we analyze the construction of nanozymes and nanobiocatalyst by different existing forms of nanomaterials including carbon-based nanomaterials, metal-based nanomaterials, and polymer-based nanocomposites. Then, we examine successful examples of such nanomaterials employed in biomedical research. The role played by nanomaterials in catalytic applications is analyzed to identify possible research directions toward the development of the field and the achievement of real practicability.

The topological nature of tag jumping in environmental DNA metabarcoding studies.

Metabarcoding of environmental DNA constitutes a state-of-the-art tool for environmental studies. One fundamental principle implicit in most metabarcoding studies is that individual sample amplicons can still be identified after being pooled with others-based on their unique combinations of tags-during the so-called demultiplexing step that follows sequencing. Nevertheless, it has been recognized that tags can sometimes be changed (i.e., tag jumping), which ultimately leads to sample crosstalk. Here, using four DNA metabarcoding data sets derived from the analysis of soils and sediments, we show that tag jumping follows very specific and systematic patterns. Specifically, we find a strong correlation between the number of reads in blank samples and their topological position in the tag matrix (described by vertical and horizontal vectors). This observed spatial pattern of artefactual sequences could be explained by polymerase activity, which leads to the exchange of the 3' tag of single stranded tagged sequences through the formation of heteroduplexes with mixed barcodes. Importantly, tag jumping substantially distorted our data sets-despite our use of methods suggested to minimize this error. We developed a topological model to estimate the noise based on the counts in our blanks, which suggested that 40%-80% of the taxa in our soil and sedimentary samples were likely false positives introduced through tag jumping. We highlight that the amount of false positive detections caused by tag jumping strongly biased our community analyses.

Primary outcomes of a femoral neck-preserving stem: a multicentre clinical-radiological analysis at 5-year follow-up.

PURPOSE: The aim of this prospective study was to evaluate the clinical-radiological outcomes of the Alteon Neck Preserving Stem (ANPS) (Exactech, Gainesville, FL, USA) implanted in four different centres by five senior hip surgeons with a minimum of 5 years of follow-up. MATERIAL AND METHOD: We conducted a multicentre prospective study that analysed 155 consecutive total hip replacements during 2014. We performed clinical-radiological analysis measuring Harris Hip Score (HHS), subjective satisfaction evaluation, radiolucencies, position of components, limb length discrepancy, heterotopic ossification, medical and surgical complications and a survival analysis at 5 years follow-up. RESULTS: Thigh pain was reported in 5 cases (3.2%), 2 of which reported mild pain, 2 moderate, and 1 severe. In 2 cases, subsidences of 3 mm were detected in the first scheduled X-ray, both related to intraoperative fractures with no progression after 3 months. The overall complication rate was 5.8% and 6 of the 9 complications were in the first 30 cases. Mean HHS improved from 42.9 points (range 37.2-55.7 points) preoperatively to 94.9 on average (range 87-98) at the end of the follow-up (p <0.01). Subjective evaluation was excellent in 130 (83.87%) cases and good in 25 patients (16.13%). CONCLUSIONS: The clinical-radiographic results of ANPS THR are satisfactory. The mid-term results are promising. However, long-term follow-up studies are necessary to confirm the validity of the concept.

Enzyme-mimicking capacities of carbon-dots nanozymes: Properties, catalytic mechanism, and applications - A review.

Nanozymes, novel engineered nanomaterial-based artificial enzymes, have been developed to overcome intrinsic drawbacks exist in natural enzymes including high-cost storage, structural instability, and chemical sensitivity. More recently, carbon dots (CDs) have received significant attention due to their biocompatibility, high catalytic activity, and simple surface functionalization, thus emerging as possible alternatives for biomedical and environmental applications. In this review, we analyze methods and precursors used to synthesize CDs with enzyme-mimicking behaviors. In addition, approaches such as doping or constructing hybrid nanozymes are included as possible strategies to enhance the catalytic performance of CDs. Recent studies have reported CDs that mimic different oxidoreductases, exhibiting peroxidase-, catalase-, oxidase/laccase-, and superoxide dismutase-like activities. Therefore, this review presents a detailed discussion of the mechanism, recent advances, and application for each oxidoreductase-like activity reported on nanozymes based on CDs nanomaterials. Finally, current challenges faced in the successful translation of CDs to potential applications are addressed to suggest research directions.

Resuperficialización de la rótula en el reemplazo primario total de rodilla: estudio comparativo a dos años de seguimiento / Patellar resurfacing in primary total knee replacement: A comparative study at two years of follow-up

Objetivo: Comparar los resultados funcionales del reemplazo total de rodilla con resuperficialización de rótula o sin resuperficialización, a los dos años de seguimiento. materiales y métodos: Estudio observacional retrospectivo de grupos comparativos de pacientes con osteoartritis sometidos a un reemplazo total de rodilla primario con resuperficialización de rótula o sin este procedimiento, entre enero de 2014 y diciembre de 2016, en dos centros de Colombia. A todos se les colocó una prótesis cementada Optetrak®. La función se evaluó antes de la cirugía y a los dos años mediante las escalas Knee Society Score (KSS), Hospital for Special Surgery (HSS) y Oxford Knee Score (OKS). Resultados:Se incluyeron 206 reemplazos totales de rodilla: 94 (grupo con resuperficialización) y 112 (grupo sin resuperficialización). La media de la edad en la cohorte de estudio era de 66.9 ± 9.7 años y el 76,7% (n = 155) eran mujeres. El tiempo quirúrgico fue más prolongado en el grupo con resuperficialización (mediana 100 min, RIC 90-110) que en el otro grupo (mediana 85 min, RIC 70-90; p <0,001). Aunque se observó una mejoría funcional antes del reemplazo total de rodilla y después, en ambos grupos, el cambio en el KSS clínico, el KSS funcional y el OKS fue mejor en el grupo con resuperficialización (p <0,05). Conclusiones: La resuperficialización de rótula durante el reemplazo total de rodilla se asoció a mejores resultados funcionales a los dos años. No obstante, los pacientes sin resuperficialización también refirieron una mejoría funcional después del reemplazo total de rodilla. Nivel de Evidencia: III

Objective: To compare the functional outcomes of total knee replacement (TKR) with and without patellar resurfacing at two years of follow-up. materials and methods: We carried out a retrospective observational study of patients with osteoarthritis who had undergone TKR with or without patellar resurfacing between January 2014 and December 2016 in two hospitals in Colombia. All patients received a cemented Exactech Optetrak prosthesis. Function was evaluated before surgery and after two years of follow-up with the Knee Society Score (KSS), Hospital for Special Surgery (HSS) and Oxford Knee Score (OKS). Results: A total of 206 TKRs were included, 94 in the group with resurfacing and 112 in the group without resurfacing. The mean age was 66.9 ± 9.7 years and 76.7% (n = 155) were female. Surgical time was longer in the group with resurfacing with a median of 100 minutes (Interquartile range-IQR: 90-110) compared to 85 minutes in the group without resurfacing (IQR: 70-90), p <0.001). Although functional improvement was observed before and after TKR in both groups, the change in clinical KSS, functional KSS, and OKS scores before and after TKR was better in the resurfacing group (p <0.05). Conclusion: Patellar resurfacing during TKR was associated with better functional outcomes at two years of follow-up. However, patients without resurfacing also reported functional improvement after TKR. Level of Evidence: III

Deterioro de la piel asociado con aseguramiento del dispositivo de acceso intravascular / Skin breakdown associated with securing of the intravascular access device / Ruptura da pele associada à fixação do dispositivo de acesso intravascular

El deterioro de la piel asociado con adhesivos de uso médico en dispositivos de acceso intra-vascular es un evento adverso que puede contribuir a la interrupción de la terapia de infusión intravascular. La Sociedad de enfermeras de infusión recomienda usar tecnologías de protec-ción como apósito estéril para aseguramiento del catéter y cinta quirúrgica para aseguramien-to complementario. Objetivo: Analizar las causas y prevalencia del deterioro de la piel aso-ciado con aseguramiento del dispositivo de acceso intravascular. Métodos: Estudio analítico, de corte transversal. Para recolectar datos se empleó un formato digital y observación directa a pacientes hospitalizados (n=813) con algún dispositivo de aseguramiento en acceso intra-vascular central o periférico, y aseguramiento complementario con cinta quirúrgica, dando seguimiento durante 7 días en febrero 2020. Resultados: El deterioro de la piel incluyó de-sprendimiento de epidermis, maceración, dermatitis irritativa por contacto y alérgica, con prevalencia de 2.2%. Se atribuyeron a catéter venoso central (f=8), catéter venoso periférico (f=7) y cinta quirúrgica para aseguramiento complementario del apósito transparente (f=3). Discusión: Las causas de deterioro de la piel se debieron al tipo de dispositivo y material implementado para aseguramiento; en la mayoría de casos las lesiones se encontraron en accesos venosos periféricos, seguida de accesos venosos centrales, siendo el aseguramiento complementario la menor causa de deterioro de la piel. Conclusiones: La técnica correcta de aplicación y retiro de insumos adhesivos de estabilización y aseguramiento del catéter intravascular evitará el desprendimiento de los mismos, lesiones de piel e interrupción de la terapia de infusión intravascular

Deterioration of the skin associated with medical adhesives in intravascular access devices is an adverse event that can contribute to the discontinuation of intravascular infusion ther-apy. The Society of Infusion Nurses recommends the use of protective technologies such as sterile dressing for catheter securing and surgical tape for supplemental securing. Objective: To analyze the causes and prevalence of skin deterioration associated with securing the intravascular access device. Methods: Analytical, cross-sectional study. To collect data, a digital format and direct observation of hospitalized patients (n = 813) were used with some device for securing in central or peripheral intravascular access, and complementary securing with surgical tape, with follow-up for 7 days in February 2020. Results: The Skin deterioration included epidermal detachment, maceration, irritant contact and allergic dermatitis, with a prevalence of 2.2%. They were attributed to central venous catheter (f = 8), peripheral venous catheter (f = 7) and surgical tape for complementary securing of the transparent dressing (f = 3). Discussion: The causes of skin deterioration were due to the type of device and mate-rial implemented for belaying; In the majority of cases, the lesions were found in peripheral venous accesses, followed by central venous accesses, with supplementary insurance being the least cause of skin deterioration. Conclusions: The correct technique for applying and removing adhesive supplies for stabilization and securing of the intravascular catheter will avoid their detachment, skin lesions and interruption of intravascular infusion therapy

A deterioração da pele associada a adesivos médicos em dispositivos de acesso intravascular é um evento adverso que pode contribuir para a descontinuação da terapia de infusão intra-vascular. A Society of Infusion Nurses recomenda o uso de tecnologias de proteção, como curativo estéril para fixação do cateter e esparadrapo para fixação suplementar. Objetivo: Analisar as causas e a prevalência da deterioração da pele associada à fixação do dispositivo de acesso intravascular. Métodos: Estudo analítico, transversal. Para a coleta de dados, uti-lizou-se o formato digital e observação direta dos pacientes internados (n = 813) com algum dispositivo de fixação em acesso intravascular central ou periférico e a fixação complementar com esparadrapo, com seguimento de 7 dias em fevereiro de 2020. Resultados: A deterio-ração da pele incluiu descolamento epidérmico, maceração, contato com irritante e dermatite alérgica, com prevalência de 2,2%. Foram atribuídos a cateter venoso central (f = 8), cateter venoso periférico (f = 7) e esparadrapo para fixação complementar do curativo transparente (f = 3). Discussão: As causas da deterioração da pele foram devido ao tipo de dispositivo e material implementado para amarração; Na maioria dos casos, as lesões foram encontradas em acessos venosos periféricos, seguidos de acessos venosos centrais, sendo a amarração suplementar a menor causa de deterioração da pele. Conclusões: A técnica correta de apli-cação e retirada de suprimentos adesivos para estabilização e fixação do cateter intravascular evitará seu descolamento, lesões cutâneas e interrupção da terapia de infusão intravascular

Institutional arthroplasty registry: what is the minimum acceptable dataset to be included in your hospital? Recommendations from a single-country national consensus using the Delphi method.

PURPOSE: Institutional arthroplasty registries are very popular nowadays; however, very few efforts have been made in order to standardize the information to be collected, thus limiting the possibility of inter-institutional data interpretation. This manuscript reports the results of a single-country consensus designed to define the minimum standardized dataset to be recorded within an institutional arthroplasty registry. METHODS: A national consensus was carried out among all members of the Colombian Society of Hip and Knee Surgeons using the Delphi method. Eleven questions and answers comprising every potential domain of an institutional registry of hip and knee arthroplasty were defined. According to the methodology, anonymous voting and multiple discussion rounds were performed. Three levels of agreement were defined: Strong consensus: equal to or greater than 80%, weak consensus between 70 and 79.9%, and no consensus below 70%. RESULTS: All of the questions reached consensus level. The minimum dataset was defined to include demographic and clinical information, intraoperative and implant details, follow-up and early complications, implant survival, and functional outcome scores, as well as the validation model to assess information quality within the database. Currently, this dataset is being implemented voluntarily by the members of our national society. DISCUSSION: A national consensus is a feasible method to build homogeneous arthroplasty registries. We recommend such an exercise since it establishes the basis to compare and add data between institutions and the joint analysis of said information in a national registry.

The effect of low-dose ketamine via patient-controlled analgesic pump on morphine consumption in the postoperative period in thoracotomies: a systematic review protocol.

REVIEW QUESTION/OBJECTIVE: The objective of this systematic review is to determine if adding low-dose ketamine to a morphine patient-controlled analgesic pump will have an impact on the total consumption of morphine during the first 72 hours postoperative in patients over the age of 15 undergoing surgery involving thoracotomy. In addition, secondary outcomes assessing the impact on pain, nausea and vomiting will be evaluated for any alteration with ketamine co-administration.

Características clínicas y epidemiológicas de los pacientes con diagnóstico de pubertad precoz central controlados en la consulta externa de endocrinología pediátrica del Hospital Nacional de Niños Benjamín Bloom en el período de 2004 al 2014 / Clinical and epidemiological characteristics of patients with a diagnosis of central precocious puberty controlled in the pediatric endocrinology outpatient clinic of the Benjamín Bloom National Children's Hospital in the period from 2004 to 2014

Pubertad precoz central (PPC) se caracteriza por la aparición de un desarrollo mamario progresivo en las niñas antes de los 8 años con posterior aparición de vello pubiano y axilar seis meses más tarde del inicio de la telarquia. La administración de análogos de la Hormona liberadora de la Gonadotropina (aGnRH) ha sido el tratamiento de elección. Estudio observacional, transversal, retrospectivo. Muestra comprendida por 61 pacientes controlados en consulta externa de Endocrinología del Hospital Nacional de Niños Benjamín Bloom en período de 2004 al 2014. Se realizó una descripción de las variables obtenidas a través de un instrumento, recolección de datos, utilizando como fuente de información el expediente clínico. El 100% de los pacientes fueron femeninos. El 95% provino de áreas urbanas. La media de edad de diagnóstico fue de 7.0 años, la edad media de inicio de síntomas 6.4 años. Todos los casos fueron idiopáticos. El síntoma inicial más frecuente fue la telarquia (n= 43, 70.4%). Recibieron tratamiento con aGnRh 29 (47.5%) pacientes, de los cuales (n=8 27.5%) lo obtuvieron por menos de un año. Talla adulta final media con tratamiento 150.5 cm, mientras que los que no recibieron 150.9. Todos los pacientes pertenecieron al sexo femenino. La mayoría (95%) son de origen urbano. La edad de diagnóstico de la enfermedad en la población estudiada concuerda con la sugerida para el manejo en guías internacionales. Todos los casos fueron idiopáticos. La talla adulta final es inferior a las obtenidas en estudios diferentes. Menos de la mitad de los pacientes recibieron tratamiento con aGnRh. Los pacientes tratados presentaron mayor velocidad de crecimiento